Conference Papers

A10: Civil & Environmental Engineering I

Parametric Study on ultimate deformation and capacity of Exdended bolted T-stub connections

Ghazanfar Anwar (United Arab Emirates University, United Arab Emirates); Florea Dinu (Politehnica University Timisoara, Romania)

Abstract

The disproportionate collapse of world trade center in September 11, 2001 is a turning point to study and enhance robustness to prevent progressive collapse of structures. This research aims to study T-stub components of beam-to-column extended bolted end plate connections under quasistatic large displacements for improving robustness. For this purpose, experimental testing and advanced numerical finite element investigations are carried out. Calibration of material model and T-Stub macro components are based on tensile data. Parametric study is carried out for T-stub macro-components with End plate thickness ranging from 10mm to 18mm and distance between the bolts ranging from 90mm to 140mm. It is concluded that numerical models replicate exact behavior of experiment. Parametric study reveals decrease in yield strength and ultimate capacity with increasing distance between the bolts and/or reducing the end plate thickness.

Experimental Investigation on the Flexural Behavior of Square CFSTs

Yosri Abdelmageed and Farid Abed (American University of Sharjah, United Arab Emirates)

Abstract

The objective of this paper is to investigate the flexural behavior of square CFST beams experimentally using 4 point bending test. The experimental program conducted in this study consists of four CFST beams and two hollow steel beams. The parameters that are considered in the experimental program are the h/t ratio and the compressive strength of concrete. The results of the experimental program were carefully evaluated and showed that the moment capacity of square CFST beams significantly increase with the decrease of the h/t ratio. The results also showed that the compressive strength of concrete has no significance influence on the moment capacity of square CFST beams. Moreover, the moment capacity and the ductility of CFST beams has significantly improved compared with the hollow steel tubes

Using Groove-Epoxy Anchorage Method to Solve Debonding of CFRP Plates Strengthened Concrete Beams

Khalid Mohamed, Jamal Abdalla and Rami Hawileh (American University of Sharjah, United Arab Emirates)

Abstract

Retrofitting and repairing of deteriorating structures have been done using several techniques. Strengthening of Reinforced Concrete (RC) members in shear with externally bonded fiber reinforced polymer (FRP) plates and sheets has been commonly accepted. It has been observed that de-bonding of the CFRP laminate and other strengthening materials is the most common type of failure. To address this issue many anchorage systems and methods have been developed. In this paper the use of bore-epoxy anchorage (Boring) system has been investigated. A total of five shear deficient RC beams were strengthened with carbon (CFRP) plates using groove-epoxy anchorage with grooves of different widths. The concrete beams were tested under four points bending. The results showed that the groove-epoxy anchorage delayed the CFRP de-bonding and increased the shear capacity of the concrete beams up to 106 % compared to the control beam.

Investigating Bond Behavior of Galvanized Steel Mesh to Concrete Surfaces

Kais Douier, Rami Hawileh, Jamal Abdalla and Waleed Nawaz (American University of Sharjah, United Arab Emirates)

Abstract

Epoxy and cement mortar adhesives are used to externally bond the GSM sheets to concrete prisms. This research presents experimental results that were conducted to monitor the bond strength between Galvanized Steel Mesh (GSM) sheets and concrete surfaces via mortar and epoxy adhesives. The GSM sheets bonded length was chosen to be 200 mm in length which represents 40% of the prism's length. Three-point bending tests are conducted on the tested specimens and load- deflection response is recorded along the with associated capacity and failure modes. Epoxy and cement mortar bonded specimens failed in cohesive and adhesive modes, respectively. The strengthened specimen bonded with cement mortar was 40% less effective as compared to that bonded with epoxy adhesives. The ductility and strength of the epoxy bonded specimen was significantly higher than the specimens bonded with cement mortar.

Flexure Behavior of RC T-Beams Externally Strengthened with Hybrid Systems

Abubakr Mohammed, Jamal Abdalla and Rami Hawileh (American University of Sharjah, United Arab Emirates)

Abstract

This paper aims to present an experimental program of three T-section RC beams externally strengthened in flexure with hybrid combinations of Aluminum Alloy (AA), Carbon Fiber reinforced Polymer (CFRP) and Galvanized Steel Mesh (GSM) laminates. Three T-beams with 2?12 longitudinal reinforcement were prepared, two of them were strengthened with hybrid laminates and the third one was used as control specimen. Flexure test was conducted on each of the three beams using four-point loading test setup until the failure of the specimens. All specimens failed in flexure and delamination was the controlling failure mode for all the strengthened specimens. Load carrying capacity of the strengthened specimens increased from 46% to 51% over the control specimen.

A11: Biomedical Engineering I

Ultrasound Enhanced Release of Transferrin Coupled Liposomes as Drug Delivery Carriers in Cancer Treatment

Nour AlSawaftah and Paul Kawak (American University of Sharjah, United Arab Emirates); Ghaleb Husseini (AUS, United Arab Emirates); Nahid Awad (American University of Sharjah, United Arab Emirates)

Abstract

Liposomes are nano-sized particles capable of providing efficient and site-specific delivery of therapeutic anticancer drugs. Further improvement to these nanocarriers can be achieved by attaching receptor-specific ligands to the surface of the liposomes to enhance selective delivery to tumor cells and limit adverse off-target effects. Our research focuses on the synthesis of transferrin (TF)-poly-ethylene glycol (PEG)-liposomes encapsulated with the model drug calcein and studying the effects of low- frequency ultrasound, applied at different power densities, on calcein release.

Investigation of the Effectiveness of Plasminogen on Liposomes to Target Breast and Colo-Rectal Cancer Cells for Drug Delivery

Afifa Farooq and Sana E Zehra Murtaza (American University of Sharjah, United Arab Emirates); Ghaleb Husseini (AUS, United Arab Emirates); Nahid Awad (American University of Sharjah, United Arab Emirates)

Abstract

Conventional treatment of cancer involves chemotherapy which leads to many adverse side effects in patients. To minimize these effects, drug delivery systems involving the use of liposomes as nanocarriers have been developed along with ligand-targeting and ultrasound as an external stimulus to ensure site-specific, and fast release of drugs. The proposed research aims to target breast and colorectal cancer cells by employing plasminogen-receptor mediated endocytosis. To achieve this, liposomes attached with plasminogen shall be synthesized and characterized using dynamic light scattering, as well as Stewart and Bicinchoninic assays. The drug release at high and low ultrasound frequencies shall be studied and then modeled.

Anti-cancer Drug Delivery Using a Novel Fe-NDC-MOF Nanocarrier

Mihad Ibrahim (American University of Sharjah, United Arab Emirates); Ghaleb Husseini (AUS, United Arab Emirates); Rana Sabouni (American University of Sharjah, United Arab Emirates)

Abstract

This paper reports the use of a new nano-metal organic framework (nanoMOF), named Fe-NDCMOF, as an anticancer drug carrier. Fe-NDC-MOF particles were prepared from iron nitrate and 2,6-naphthalenedicarboxylic acid using the microwave irradiation method. They have dimensions of 50-80 nm ? 300-450 nm with pore diameters of 14.855 nm. Calcein disodium salt (a fluorescent model drug mimicking antineoplastic agents) was loaded successfully in this MOF with high loading efficiency (99.15%) and capacity (43.27 wt.%). Moreover, Fe-NDC-MOF managed to entrap Doxorubicin hydrochloride (DOX.HCl, a widely used chemotherapeutic drug) in an attempt to alleviate its serious side effects on healthy cells (especially cardiotoxicity). The encapsulation efficiency and capacity were found to be 67.5%, and 11.8 wt.%, respectively. It was concluded that, Fe-NDC-MOF can be utilized to design smart targeted anticancer drug delivery systems.

Solution Stability of Biological Coatings for Nanoparticles

Nahla Rizk and Matthew Martin (Khalifa University, United Arab Emirates)

Abstract

Nowadays, gold nanoparticles (AuNPs) are integrated into many biological systems like in vitro and in vivo imaging, cancer therapy, and drug delivery. The stability of AuNPs as drug carriers in a drug delivery system is poorly investigated which could result in less efficient treatments. Coating AuNPs with different biological coatings can have different optical, thermal, and chemical properties which results in variant stability limits in different environments. Investigating the adsorption process of biological coatings on the surface of AuNPs is essential to control the biological interactions of functionalized AuNPs. The goal of this project is to study the stability of coated AuNPs in different environmental. The biocompatible coatings of AuNPs used are polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP). In this project, the coated AuNPs are destabilized with different concentrations of different acids, salts, and bases, and the changes can be measured using UV-Vis light, and dynamic light scattering (DLS).

The Effect of Ultrasound on the Drug Delivery of Arginine-Glycine-Aspartic Acid Peptide-Targeted Liposomes to Cancer Cells

Mohamad Mahmoud (American University of Sharjah, United Arab Emirates); Ghaleb Husseini (AUS, United Arab Emirates)

Abstract

Approaches used to treat cancer, with the most prominently used being chemotherapy, have detrimental effects on patients' health. Doxorubicin, a chemotherapeutic agent, alters normal cellular functions and can cause many fatal side effects, such as cell loss and congestive heart failure. Smart Drug Delivery Systems (DDS), such as liposomes, is a novel approach which can deliver a cytotoxic agent into the tumor without affecting healthy cells. Liposomes are nanocarriers capable of delivering an encapsulated cytotoxic agent, such as Doxorubicin, to specific tumor tissue or organ. A moiety, such as an RGD motif, can be attached to the liposome's surface. This modification increases the efficacy of such liposomes by actively targeting specific receptors which are overexpressed in certain types of cancer cells. Ultrasound waves can be used to trigger the liposomes into releasing their encapsulated content, such as the chemotherapeutic agent, at the tumor site. The triggered release of these liposomes is to be studied using low frequency (20kHz) ultrasound, at several power densities, by monitoring the fluorescence of a model drug (calcein). The presentation will outline the preparation of the smart DDS (liposomes), evaluate its success as a nanocarrier, as well as its stability and storage, and analyze its drug release and sensitivity to ultrasound.

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