This paper presents a queuing algorithm to find minimal number of VMs to satisfy Service Level Object (SLO) response time. The algorithm ensures the quality of service (QoS) by using the minimal number of required VMs to satisfy user service agreement conditions (response time). Based on queuing theory the model is built to increase the system performance by minimizing waiting time for servers and using resources with its maximum capacity.
The growing research on networks during the past decade facilitated the understanding of the underlying structure behind complex networks whether they are linked to biological, social, or political systems. In this work, we examine the evolution of connectivity and activity dynamics in the Bitcoin transaction graph to get more insights into the change of its structural and functional properties over time. While some of the properties under investigation are specific to the Bitcoin environment, others are generic and hence are compared with the same properties examined previously in various social and information networks. Previous research identified two distinct evolutionary stages of Bitcoin i.e., the initial stage and the trading stage. Our results reveal that during the trading stage the Bitcoin transaction graph started approximately resembling other real-world networks, moreover user activities differ noticeably throughout these stages.
Hajj is the fifth pillar of Islam, in which millions of Muslims from all over the world congregate to perform religious rituals in Mecca at fixed determined days. In spite of the tremendous effort geared towards facilitating the Hajj activities to pilgrims, the authority and Hajj organizers face great difficulties to manage and control the various inherent Hajj processes. The cases of missing pilgrims, massive crowd fatalities; safety violations and knowledge unawareness become major and challenging issues. Although several solutions have been introduced, the need for an efficient smart monitoring and controlling solutions become a vital necessity. This paper proposes a novel approach that can provide efficient means, guidelines Hajj Pilgrims that utilize the Internet of Things (IoT) phenomena and wearable technology. Therefore, we proposed wearable devices solution that are electronic strap and smart glass to be provided to pilgrims, as well as applications for organizers to overcome these difficulties.
Muscle, skeletal, receptor tyrosine kinase (MuSK) is the key organizer at the postsynaptic membrane and critical for proper development of the neuromuscular junction. Mutations in MUSK result in congenital myasthenic syndrome (CMS). It was hypothesized that the CMS-causing missense mutation (P344R), found within the cysteine-rich domain of the protein, will affect its conformational tertiary structure. Consequently, the protein will misfold, get retained in the endoplasmic reticulum (ER) and lose its biological function through proteasomal degradation. Investigating the molecular mechanism of missense mutations is important since ER-targeted therapies are in development. P344R-MuSK mislocalized to the ER, was improperly N-glycosylated and tagged with polyubiquitin chains, prerequisites for proteasomal degradation. Proteasomal inhibition resulted in an increased half-life of the mutant. P344R-MuSK's trafficking defect was rescued by expression at 27 ?C and with chemical chaperones. These findings open perspectives for potential therapeutic intervention for patients with CMS harboring the P344R-MuSK mutation.
Pancreatic cancer is the most fatal disease amongst all solid malignancies. Understanding the sequential additive genetic alterations in its pathogenicity is essential. Via global expression profiling, TTMP gene was found to be involved in the genetic evolution of pancreatic cancer. To better understand the role of the TTMP gene, specific anti-TTMP antibodies against unique C- and N-terminus peptides were generated. Five rabbits were immunized with each of the two conjugated peptides. Animals were bled regularly and antibody titers were checked by ELISA. Western blotting was used to assess the antibodies. Significant antibodies titers against the C- and N-termini were generated in all animals. Antibodies worked well for western blotting in detecting the same molecular weight protein. These highly specific antibodies can serve a pivotal role in further studies to characterize the TTMP gene and expand our knowledge of its role in the context of pancreatic cancer pathogenesis.
The objective of this study was to determine the frequency of ABO, Rhesus phenotype and most probable genotypes in Al Ain area. The studied group consisted of 500 locals of both gender from different age groups. ABO and Rh-hr phenotype reactivity were determined using conventional tube method and gel technology. Our study shows the distribution of ABO phenotypes was as follows: O = 56%, A = 26.2%, B= 14.2% and AB= 3.6%. The distribution of Rh antigens was as follows: D=90.4 %, C= 76.2%, E= 27.2%, c= 71.6% and e= 97.8%. And the distribution of most probable genotypes was as follows: R1 r = 29.8%, R1 R1 = 28.4%, R1 R2 =16.8%, rr= 8.4%, R2 r= 8.2%, Ro r=5%, R2 R2 =2.2%, and r'r = 1.2%. Our study showed that the most frequent antigen amongst five major antigens of Rh system was RhD while the least common was E antigen.
Mason-Pfizer Monkey Virus is a non-primate, D-type simple retrovirus that is being studied intensively recently with the hope of using MPMV-based vectors for gene therapy. RNA structure of the MPMV RNA packaging sequences has identified two Long Range Interactions (LRI-I and II) between the U5 and Gag sequences (Fig 1A). Such LRIs have been suggested to an important role in the viral RNA packaging and propagation. Genetic analysis of the LRI-II mutants suggests that the presence of LRI-II primary sequence in its native structural context is critical for the packaging and propagation of the viral RNA.
In UAE population, the analysis of the allele frequency shows that each locus has a predominant allele and the most loci are clustered over narrow range. The UAE population is largely heterogeneous and a total of 301 different haplotypes were identified. There are 271 unique haplotypes and 22 haplotypes were shared between two individuals. There are three cases where four, five and six individuals are sharing identical haplotype. This is likely due to the sharing of most common recent ancestors. This brings the discrimination capacity to approximately 90% and haplotype diversity 99.885%. This is fundamental to understanding the degree of heterogeneity in UAE population and can reflect the pattern of the migration, geographic influence, and cultural influences. Secondly, United Arab Emirates population is diverse and are genetically close to neighboring countries. Analysis of molecular variance show no significant genetic differences within UAE population or population residing the Arabian Gulf region.
In this paper we propose to extend the maximum principle and the method of upper and lower solutions to boundary value problems with Caputo fractional derivative. At first, we transform the problem to a system of two equations, one with fractional derivative and the second one with integer derivative. We then establish a new positivity result and apply it to introduce two well-defined monotone sequences of pairs of lower and upper solutions to obtain existence and uniqueness results for the problem.
Initial value problems with irregular singular points are very important for researchers in various fields including science and engineering. Series solution of these kinds of problems is not easily achieved at the point of singularity, and the numerical techniques are not capable to solve the problem due to the fact that calculations will require a division by 0. In addition, numerical solutions of boundary value problems are very limited; it includes finite difference method and shooting method. This initiates the need for a development of new techniques to handle these problems. In this article we will discuss a new method based on a modified Tylor series approach to solve initial value problems with irregular singular at certain points in the domain of definition of the problem and boundary value problems in general. The method is based on expanding of the solution at different choices of the expansion point
