With technical innovations being a dynamic force behind economic growth for many countries worldwide, apprehensions are emerging related to the decreasing numbers of individuals who are joining the technical career domains. The under-representation of women in science, technology, engineering and mathematics (STEM) fields drastically reduces the available talent pool that would aid in enhancing technical innovation. The literature still falls short on explaining and uncovering the factors that might contribute to females' persistence and commitment in STEM fields. The aim of this study is to try to understand the factors that might affect female persistence and occupational commitment in these fields through qualitative analysis. Only a small number of researches have attempted to investigate women's persistence in STEM fields from a cognitive perspective, thus a qualitative research is deemed pertinent to try to comprehend the aspects behind the career decisions of persisting women. Our aim is to heighten the attention on the process elements of persistence and occupational commitment of females working in STEM fields. We attempt to shed light on the dynamic approaches adopted by females in STEM fields to overcome occupational challenges. The theoretical framework for this reach is the career selfmanagement model, an updated model of the social cognitive career theory which draws from Bandura's initial cognitive work and attempts to enhance and draw links between previous theoretical domains and career development.
The present workforce need assurance in future that HR planning must analyze the competence of the current workforce. Comparing future requirements with current workforce abilities will identify weaknesses or surplus. Checking workforce surpluses and deficits human resource must prepare action plans for the workforce {5}This include identifying the type and number of employees needed, employee competency,recruiting,retaining measures,training of employees etc.In theory, both government dictated labour legislations and organization implemented human resource practices should focus on employee well being. The actual practice of these theories is not clear. This study will try to analyse the actual human resource practices of holding companies in UAE and their compliance with the labour laws of the country, Mixed research approach will be used for this study The study will reveal the human resources practices of holding companies in UAE, the reasons why UAE locals avoiding work in Holding companies
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide. Targeting cancer stem cells, the multi drug resistant population, is extremely challenging. The aim of this work was to exploit the mechanistic synergy between Energy restriction mimetic agents (ERMAs) as OSUCG5 and a conventional chemotherapeutic agent as doxorubicin to counteract cancer multidrug resistance. The generated doxorubicin-resistant breast cancer cells (MCF-7 and MDA-231 cell lines) showed less sensitivity to doxorubicin and an increase in breast cancer CD44+/CD24low cells, in addition to an increase in the expression of ABC proteins. The treatment of these cells with doxorubicin in combination with OSU-CG-5 overcame their resistance and showed a significant synergistic effect. The results suggested that targeting breast cancer by ERMAs could be a rational strategy to minimize their multi-drug resistance, and the combination with classical chemotherapeutic agents may represent a clinically relevant strategy for cancer treatment improving the survival of patients.
Pontocerebellar hypoplasia type 9 (PCH-9) is an autosomal recessive neurodegenerative disorder caused by loss of function variants in AMPD2 gene. We clinically evaluated an Emirati patient presented with severe developmental and growth delays. We performed exome sequencing, Sanger sequencing and segregation analysis followed by in silico and in vitro analysis to elucidate the pathogenicity of the variant, we also ran a population ancestry analysis of likely pathogenic variants on ExAC database. We identified the novel mutation (c.1633G>A) in AMPD2 gene. This variant is predicted to be pathogenic using several in silico tools, and resulted in a decrease in the enzyme function in the patient's polymorphonuclear cells (PMNCs) by 82% (95% CI: 73.3-91.7%, p=0.029) compared to control. This data establishes that the affected child is affected by PCH-9. In addition, population analysis of AMPD2 variants confirmed the presence of potentially disease causing mutations in non-Middle-Eastern populations.
Cancer is the second leading cause of death worldwide. Conventional therapies cause serious side effects. There is an increasing demand to utilize alternative approaches to the prevention of cancer. The objective of this research is to screen and identify new synthetic compounds for breast cancer therapy. We have synthesized newly designed chromenes and tested them for their potential anticancer activities against the triple negative breast cancer (TNBC). They significantly inhibited, in time- and concentration-dependent manner, the viability of the breast cancer cell lines and induced apoptosis as well. Furthermore, cell cycle distribution analysis on chromenestreated cells revealed that the cell underwent a mitotic arrest confirmed by an increased expression of the M phase specific marker, p(ser10) histone H3. Further investigations are underway to elucidate the molecular mechanism(s) through which chromenes exerts their anticancer effects. Our current study provide evidences that chromenes could be a potential therapeutic compounds against the TNBC.
Project Abstract: Cancer cells have truncated iron metabolism which is thought to increase the reactive oxygen species stress that might contribute in colorectal cancers development and progression. In this paper we investigated the role of 5 iron regulator proteins; Transferrin Receptor 1 and 2, Ferroportin, Ferritin and Catalase, on the development and progression of colorectal cancer (CRC) by Western blot, immunohistochemistry. In addition, we analyzed 2 more proteins that interacted with these iron regulators, affecting the overall iron metabolism process, Heme oxygenase-1 and Hepcidin.
Natural Killer (NK) cells, innate immune cells with a potential anti-tumor activity, can be used to target solid tumors such as colorectal cancer. In an attempt to increase their migration to tumor sites, drugs such as dimethyl fumarate (DMF) or monomethyl fumarate (MMF) are used to increase chemokine receptors expression and thus chemotaxis. NK92 cells were used where they were found to migrate towards CCL27, CCL28 and CXCL16, proposed chemokine ligands released by colorectal cancer cells. This has been supported by NK92 migration towards the supernatant collected from HCT-116, a colorectal cancer cell line. This migration pattern was enhanced by treatment with 100 ?M of DMF or MMF. Additionally, the respective receptors CCR10 and CXCR6 expression were upregulated on NK92 cells upon pretreatment. Therefore, this study highlights the potential of NK cells to be used for cancer immunotherapy by directing them to tumor sites.
This paper will look into the supremacy of neoliberalism and its impact in both inappropriate and ineffectiveness of managing forests in the private and commercial sector. That has caused the failure of forestry protection thus resulting to high deforestation. In the effort to protect the forests, this paper discusses the need for international convention in the support and facilitation of community forestry which is a successful forest conservation tool in dissimilar countries especially in Africa e.g. Tanzania. The global community has to apply global principles and enforce them locally in order to ensure maximum conservation and protection of the most common features such as forests. This research uses a case study methodology to help address the research objectives and research problems. In order to examine how neoliberalism dominance has constrained collective environmental action, the paper discusses neoliberalism policies particularly in Brazil in the discussion section. This paper reached a conclusion stating that ,the International Forest Policy's main work is to bring up international collective action, which is currently fragmented with no coherent forest conventions existing, keeping in mind that forest are a common pool of resources.
The natural radioactivity concentrations of 238U (226Ra),232Th and 40K were estimated in beach sand near Barakah NPP, using gamma spectrometry using HPGe detector. The average activity concentrations of 238U (226Ra), 232Th and 40K are 4.43?3.88,1.68?1.71, and 106.3?7.27 Bq/kg, respectively. In addition, the hazard parameters such as Radium equivalent and absorption dose were estimated. The current estimated activity concentrations were lower than levels reported in nearby countries and the world average.
The current research work is carried out for the biological treatment of sewage water for different valuable purposes. Four interconnected ponds were designed for the biological treatment of sewage water to check its suitability for different experimental species. Anaerobic bacteria were introduced into pond 1 to biodegrade the sewage contaminants and to generate methane gas. Aerobic bacteria and phytoremediation plants were introduced into pond 2 for bioremediation purposes. Sand and gravel filter was also applied on pond 2 water to provide biofilm for bacteria and to eliminate left over heavy metals. In Pond 3, Tilapia fish was introduced for bio-filtration and fresh water fish farming. Water from pond 3 directly drained into pond 4 for irrigation purposes. Physicochemical parameters were demonstrated a significant decrease in water turbidity, conductivity, pH and heavy metal concentrations from pond 1 towards pond 4. Similarly, Microbial analysis were identified no major pathogen in the biologically treated sewage water.
